Experimental study demonstrates additive-free oximophosphinothiolation of alkenes, highlighting an efficient route to functionalized oximes.
A simple and efficient oximophosphinothiolation of alkenes with sodium nitrite, elemental sulfur, and secondary arylphosphines has been developed. This transformation can be carried out under mild and additive-free conditions, employing NaNO2 and S8 as the NO source and sulfur source, respectively. A wide variety of α-dithiophosphinate oximes could be accessed via this method in moderate to good yields, and the reaction showed good tolerance to diverse functional groups.
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Hou et al. (2026) studied this question.
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