What question did this study set out to answer?

Evaluate the effectiveness and safety of methylprednisolone pulses in newly diagnosed giant cell arteritis patients.

Methylprednisolone pulses are associated with faster remission in Giant Cell Arteritis: a multicentre inception cohort study

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Observational study shows faster remission in giant cell arteritis with methylprednisolone pulses, suggesting a need for broader application.

Evaluate the effectiveness and safety of methylprednisolone pulses in newly diagnosed giant cell arteritis patients.
Retrospective observational multicentre study
Compared induction therapy with methylprednisolone versus oral glucocorticoids
Utilized inverse probability weighted regression adjustment for analysis
95.1% of patients achieved remission; median time was 8.6 weeks
Methylprednisolone reduced time to remission by 14.2 weeks on average (p < 0.001)
Higher hazard of remission with methylprednisolone (HR 2.44, p < 0.001)
Lower median cumulative prednisone dose in methylprednisolone group (733 mg vs. 1,902 mg; p < 0.001)
Fewer cases of diabetes and osteoporosis in the methylprednisolone group at 3 months.

Guitián et al. (2026) studied this question.

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Observational study shows faster remission in giant cell arteritis with methylprednisolone pulses, suggesting a need for broader application.