Recent findings reveal that oncolytic viruses can reverse immune suppression in glioblastoma, suggesting new treatment options.
Glioblastoma multiforme (GBM) is a lethal primary brain cancer for which treatment has limited options, characterized by systemic and local immunosuppression that contributes to the malignancy's aggressiveness and resistance to therapy.In a recent study published in Cellular and Molecular Immunology [1], Han et al. reported that intravenously administered oncolytic alphavirus M1 not only suppressed GBM growth but also reversed GBM-induced systemic immunosuppression.
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Dieli et al. (2026) studied this question.
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