Network meta-analysis compares intracerebral haemorrhage risk of tenecteplase and alteplase in acute ischaemic stroke, suggesting optimal dosing.
TNK at 0.25 mg/kg may offer the most favorable balance of safety and efficacy for AIS. In contrast, the 0.4 mg/kg dose was associated with increased haemorrhagic risk and lower safety rankings.
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Fernandes et al. (2026) studied this question.
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