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July 16, 1992New England Journal of Medicine

The Use of Aspirin in Ischemic Heart Disease

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Population

Patients with ischemic heart disease

Design

Review

Authors

JDJane F. DesforgesTufts UniversityJWJohn E. WillardTulane UniversityRLRichard A. LangeInterventional / Structural Cardiology

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Overview

Provides foundational antiplatelet rationale in ischemia; leaves open dosing refinements for contemporary cohorts.

Key Points

  • This research investigates the role of aspirin in mitigating thrombi formation in ischemic heart disease.
  • Review of historical uses of aspirin for analgesia and antipyresis
  • Examination of prostaglandin synthesis inhibition mechanism
  • Analysis of aspirin's effects on platelet aggregation and thrombus formation
  • Aspirin effectively inhibits prostaglandin synthesis, contributing to reduced platelet aggregation
  • Platelet aggregation is linked to the pathophysiology of ischemic heart disease
  • Growing evidence supports aspirin's use in individuals without diagnosed ischemic heart disease

Structured PICO

P
Population
Patients with ischemic heart disease
I
Intervention
Aspirin

Cite This Study

Desforges et al. (1992) studied this question.

synapsesocial.com/papers/69c0251446f5f4fe05a0d00ahttps://doi.org/10.1056/nejm199207163270308
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Secondary prevention of vascular disease by prolonged antiplatelet treatment1988 · 1,051 citations
  2. 2Improved graft patency in patients treated with platelet-inhibiting therapy after coronary bypass surgery.1985 · 167 citations
  3. 3Is vasospasm related to platelet deposition? Relationship in a porcine preparation of arterial injury in vivo.1987 · 213 citations
  4. 4Failure of Antiplatelet and Anticoagulant Therapy to Improve Patency of Grafts after Coronary-Artery Bypass1979 · 172 citations
  5. 5Aspirin and dipyridamole in the prevention of acute coronary thrombosis complicating coronary angioplasty.1987 · 325 citations