Key result
Aspirin was first hypothesized to protect against MI in 1953 based on increased bleeding observations.
Why the study?
Despite widespread use of aspirin for its cardioprotective effects, some individuals exhibit resistance to these benefits, and the reasons remain unclear.
Design
Review
Authors
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Empirical origins of antiplatelet therapy inform current debates; leaves open refined aspirin indications in primary prevention.
Halushka et al. (2002) reported a review. Aspirin was evaluated. Aspirin was first hypothesized to have antithrombotic and cardioprotective effects against myocardial infarction in 1953 based on observations of increased bleeding.
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