Inhaled nitric oxide reduced pulmonary vascular resistance by 3.21 Wood units compared to control at 30 minutes in patients with acute severe right heart failure and pulmonary hypertension.
RCT (n=30)
Open-label
1:1
No
Does inhaled nitric oxide reduce pulmonary vascular resistance in patients with acute severe right heart failure due to pulmonary hypertension?
Inhaled nitric oxide rapidly and safely reduces pulmonary vascular resistance and improves markers of right ventricular overload in patients with acute severe right heart failure due to pulmonary hypertension.
Effect estimate: Mean difference -3.21 Wood units (95% CI -4.633 to -1.785)
Absolute Event Rate: -2.41% vs 0.8%
Background: Acute right heart failure (RHF) is life threatening in patients with pulmonary hypertension (PH). This study investigated the efficacy and safety of inhaled nitric oxide (iNO; INOflo®for inhalation 800 ppm), a rapid pulmonary vasodilator, in patients with acute severe RHF due to PH.
Ogo et al. (2026) conducted an RCT in Acute severe right heart failure with pulmonary hypertension (n=30). Inhaled nitric oxide (iNO) vs. Control (no iNO) was evaluated on Change in pulmonary vascular resistance (PVR) from baseline to 30 minutes (Mean difference -3.21 Wood units, 95% CI -4.633 to -1.785). Inhaled nitric oxide reduced pulmonary vascular resistance by 3.21 Wood units compared to control at 30 minutes in patients with acute severe right heart failure and pulmonary hypertension.