Study reveals fibrinogen αC domain boosts plasmin generation in platelets, suggesting new insights into hemostasis.
C-terminal lysine residue(s) generated during thrombin-mediated platelet stimulation within the αC domain of fibrinogen confers maximal plasminogen binding and subsequent plasmin generation that is sensitive to suppression by TAFIa.
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Aftabjahani et al. (2026) studied this question.
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