September 30, 2014JAMA
Survival and Long-term Outcomes Following Bioprosthetic vs Mechanical Aortic Valve Replacement in Patients Aged 50 to 69 Years
Why the study?
Does bioprosthetic aortic valve replacement improve 15-year survival or stroke compared to mechanical aortic valve replacement in patients aged 50 to 69 years?
Population
Propensity-matched patients aged 50 to 69 years undergoing aortic valve replacement
Comparison
Bioprosthetic aortic valve replacement vs Mechanical aortic valve replacement
Design
Cohort
Follow-up
15 years
Authors
Discussion
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Member takes
Implication
Should not yet change valve selection in patients aged 50-69; leaves open need for randomized confirmation of durability versus bleeding trade-offs.
Structured PICO
Does bioprosthetic aortic valve replacement improve 15-year survival or stroke compared to mechanical aortic valve replacement in patients aged 50 to 69 years?
P
Population
Propensity-matched patients aged 50 to 69 years undergoing aortic valve replacement
I
Intervention
Bioprosthetic aortic valve replacement
C
Comparator
Mechanical aortic valve replacement
O
Outcome
15-year survival and strokehard clinical
In patients aged 50 to 69 years, bioprosthetic aortic valves offer similar 15-year survival and stroke rates as mechanical valves, with a trade-off of higher reoperation risk but lower major bleeding risk.
Cite This Study
Chiang et al. (2014) studied this question.