Predictive Performance of HOMA-IR and TyG Index Across FTO rs9939609 Genotypes in Type 2 Diabetes Mellitus

Dinesh Kumar; Jyoti Batra; Abhishek Pandeya; Saraswati Sah; Sudeep Kumar; Juhi Aggrawal

doi:10.1016/j.cegh.2026.102348

March 1, 2026Clinical Epidemiology and Global HealthOpen Access

Predictive Performance of HOMA-IR and TyG Index Across FTO rs9939609 Genotypes in Type 2 Diabetes Mellitus

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Key Points

This research aims to evaluate the predictive performance of insulin resistance indices based on FTO rs9939609 genotypes in Type 2 Diabetes Mellitus individuals.
Conducted a case-control study with 120 Type 2 Diabetes patients and 120 healthy controls.
Measured fasting glucose, triglycerides, lipid profile, and insulin levels.
Calculated HOMA-IR and TyG indices.
Performed genotyping of FTO rs9939609 using PCR-RFLP.
Applied logistic regression and ROC analysis to assess performance of IR indices.
A allele was significantly more common in T2DM cases (43.9%) compared to controls (27.9%).
Both TyG and HOMA-IR values increased with A allele presence from TT < AT < AA genotypes.
In the additive model, TyG showed an odds ratio (OR) of 2.84 and HOMA-IR an OR of 2.39 for T2DM.
ROC analysis indicated that TyG had superior discriminatory performance (AUC=0.742) compared to HOMA-IR (AUC=0.666).

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Implication

Case-control study reveals TyG index is a better predictor of insulin resistance in Type 2 Diabetes across genotypes, suggesting improved screening methods.

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Cite This Study

Kumar et al. (2026) studied this question.

synapsesocial.com/papers/69c2294caeb5a845df0d3909 https://doi.org/10.1016/j.cegh.2026.102348

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Predictive Performance of HOMA-IR and TyG Index Across FTO rs9939609 Genotypes in Type 2 Diabetes Mellitus

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Predictive Performance of HOMA-IR and TyG Index Across FTO rs9939609 Genotypes in Type 2 Diabetes Mellitus

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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