What question did this study set out to answer?

This research aims to characterize a novel RHD variant and examine its effects on antigen expression.

March 24, 2026Vox Sanguinis

A novel RHD allele (c.727 T>G) associated with reduced D antigen expression in a pregnant Chinese woman

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Research characterizes a novel RHD variant impacting antigen expression in a pregnant woman, suggesting methods for classification refinement.

This research aims to characterize a novel RHD variant and examine its effects on antigen expression.
Analyzed full-length RHD gene using PacBio SMRT long-read sequencing.
Evaluated protein stability effects using DynaMut2.
Executed amino acid interaction analysis with LigPlot.
Performed structural visualization with PyMOL.
Proband identified as heterozygous for RHD*15 and c.727T>G (p.Tyr243Asp) variants.
Structural predictions indicated weakened hydrophobic interactions and decreased protein stability.
Novel allele may jointly contribute to reduced RhD antigen expression.

Li et al. (2026) studied this question.

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Research characterizes a novel RHD variant impacting antigen expression in a pregnant woman, suggesting methods for classification refinement.