What question did this study set out to answer?

To investigate if lipid mediator profiles can serve as biomarkers for asthma phenotypes.

Urinary LTE ₄ may be associated with TH2-driven asthma: Initial data from the Pan-European U-BIOPRED IMI project

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Cross-sectional analysis reveals urinary LTE4 links to decreased lung function in adult asthma phenotypes, suggesting TH2-driven inflammation.

To investigate if lipid mediator profiles can serve as biomarkers for asthma phenotypes.
Cross-sectional analysis of adults with asthma and healthy controls.
Measured urinary concentrations of lipid mediators including cysteinyl-leukotrienes.
Analyzed samples using UPLC-MS/MS.
Higher urinary excretion of lipid mediators in severe asthma compared to mild-to-moderate asthma and healthy controls.
LTE4 showed significant median fold increases in severe (MFC=2.1) and mild-to-moderate asthma (MFC=1.5).
Correlation of LTE4 with low lung function and increased total IgE levels, exhaled NO, and eosinophils.

Sjödin et al. (2014) studied this question.

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Cross-sectional analysis reveals urinary LTE4 links to decreased lung function in adult asthma phenotypes, suggesting TH2-driven inflammation.