February 26, 2010European Journal of Clinical Investigation
Sulfido‐peptide leukotrienes in coronary heart disease – relationship with disease instability and myocardial ischaemia
Why the study?
Is urinary leukotriene E4 excretion increased in patients with acute coronary syndromes compared to stable angina and controls?
Population
62 subjects including 17 patients with chronic stable angina, 3 with Prinzmetal's angina, 16 with non…
Design
Cross-sectional
Authors
Discussion
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Implication
Urinary LTE4 elevation associates with ACS but not stable angina; hypothesis-generating for leukotriene-targeted interventions.
Structured PICO
Is urinary leukotriene E4 excretion increased in patients with acute coronary syndromes compared to stable angina and controls?
P
Population
62 subjects including 17 patients with chronic stable angina, 3 with Prinzmetal's angina, 16 with non ST-elevation acute coronary syndromes (NSTE-ACS), 6 with acute ST-elevation myocardial infarction (STEMI), 11 healthy controls, and 9 non-coronary cardiac controls. A subset included 10 patients undergoing single-vessel PCI and 9 undergoing diagnostic angiography.
C
Comparator
Healthy controls and non-coronary cardiac controls
O
Outcome
Urinary excretion of leukotriene E4 (LTE4) measured by enzyme immunoassay after HPLC separationsurrogate
Increased leukotriene C4 biosynthesis is restricted to acute coronary syndromes and likely linked to plaque disruption rather than myocardial ischemia per se.
Cite This Study
Caterina et al. (2010) studied this question.