February 1, 1988Cardiovascular Research

Detection of leukotriene B4 in cardiac tissue and its role in infarct extension through leucocyte migration

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Why the study?

Does a selective 5-lipoxygenase inhibitor reduce infarct size in a rat model of myocardial infarction?

Population

Rat model of myocardial infarction induced by main left coronary artery ligation

Comparison

Selective 5-lipoxygenase inhibitor vs Sham operated hearts / untreated controls

Design

Preclinical

Follow-up

48 hours

Authors

KSKazuto SasakiThe University of Tokyo AUAtsushi UenoTokyo Metropolitan University MKMakoto KatoriChuo University

Discussion

Member takes

Implication

Hypothesis-generating for 5-lipoxygenase inhibition in MI; human studies required before clinical consideration.

Structured PICO

Does a selective 5-lipoxygenase inhibitor reduce infarct size in a rat model of myocardial infarction?

Population

Rat model of myocardial infarction induced by main left coronary artery ligation

Intervention

Selective 5-lipoxygenase inhibitor (AA-861, 80 mg/kg single oral dose 1 h before ligation)

Comparator

Sham operated hearts / untreated controls

Outcome

Infarct size at 48 hourssurrogate

Inhibition of 5-lipoxygenase reduces leukotriene B4 production, leucocyte migration, and infarct size in a rat model of myocardial infarction.

Cite This Study

Sasaki et al. (1988) studied this question.

synapsesocial.com/papers/6a701f69f44fa9f079ddaafd https://doi.org/10.1093/cvr/22.2.142

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Detection of leukotriene B4 in cardiac tissue and its role in infarct extension through leucocyte migration

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Detection of leukotriene B4 in cardiac tissue and its role in infarct extension through leucocyte migration

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider