December 1, 1992Cardiovascular Research

Peptide leukotriene receptor antagonism in myocardial ischaemia and reperfusion

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Why the study?

Does LY-171883 reduce myocardial ischaemia-reperfusion injury in an adult male cat model?

Population

Adult male cats subjected to left anterior descending coronary artery occlusion for 3 hours followed by 3…

Comparison

LY-171883 administered intravenously during the… vs Vehicle

Design

Preclinical

Follow-up

3 hours

Authors

CHCarl E. HockRutgers, The State University of New Jersey LBLeslie D. BeckInserm LPL. A PapaRowan University

Discussion

Member takes

Implication

Supports leukotriene antagonism for cardioprotection in animal models; leaves open translation to human ischaemia-reperfusion injury.

Structured PICO

Does LY-171883 reduce myocardial ischaemia-reperfusion injury in an adult male cat model?

Population

Adult male cats (2.9-5.4 kg) subjected to left anterior descending coronary artery occlusion for 3 hours followed by 3 hours of reperfusion

Intervention

LY-171883 (peptide leukotriene receptor antagonist) administered intravenously during the reperfusion period (3 mg/kg bolus; 3 mg/kg/h infusion)

Comparator

Vehicle

Outcome

Ischaemic injury assessed by necrotic area (nitroblue tetrazolium staining) and tissue creatine kinase activitysurrogate

Peptide leukotriene receptor antagonism with LY-171883 significantly reduces myocardial infarct size in a feline model of ischaemia-reperfusion injury.

Cite This Study

Hock et al. (1992) studied this question.

synapsesocial.com/papers/6a7358f7c72fde7964b86f2e https://doi.org/10.1093/cvr/26.12.1206

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Peptide leukotriene receptor antagonism in myocardial ischaemia and reperfusion

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Peptide leukotriene receptor antagonism in myocardial ischaemia and reperfusion

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider