Why the study?
Does selective TxA2 synthetase inhibition with U63,557A reduce reperfusion injury and arrhythmias in a canine model of coronary occlusion and reperfusion?
Population
17 dogs subjected to total coronary occlusion for 1 hour and reperfusion for 1 hour
Comparison
Selective TxA2 synthetase inhibitor U63,557A… vs Saline
Design
Preclinical
Follow-up
1 hour of reperfusion
Authors
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Supports preclinical testing of TxA2 inhibition in reperfusion; leaves open clinical translation.
Does selective TxA2 synthetase inhibition with U63,557A reduce reperfusion injury and arrhythmias in a canine model of coronary occlusion and reperfusion?
Selective TxA2 synthetase inhibition decreases reperfusion arrhythmias and preserves myocardial function in a canine model of ischemia-reperfusion, though it does not prevent microvascular leukocyte plugging or deterioration in reactive hyperemia.
Mehta et al. (1990) studied this question.
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