Key result
In a cat model of acute myocardial ischemia, the TxA2 receptor antagonist SQ-29,548 significantly reduced S-T segment elevation (p<0.01) and attenuated the rise in plasma creatine kinase (p<0.05).
Why the study?
Does SQ-29,548 reduce myocardial damage in a cat acute coronary ligation model of myocardial ischemia?
Population
Cat acute coronary ligation model of myocardial ischemia
Comparison
SQ-29,548 vs Vehicle
Design
Preclinical
Follow-up
5 hours
Authors
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May implicate TxA2 in feline ischemia; hypothesis-generating and should not yet change practice.
Does SQ-29,548 reduce myocardial damage in a cat acute coronary ligation model of myocardial ischemia?
p-value: p=<0.01
The TxA2 receptor antagonist SQ-29,548 reduces myocardial damage in a cat model of acute myocardial ischemia, highlighting the role of TxA2 in ischemic injury.
Brezinski et al. (1987) studied Acute myocardial ischemia. SQ-29,548 vs. Vehicle was evaluated on S-T segment elevation (p=<0.01). In a cat model of acute myocardial ischemia, the TxA2 receptor antagonist SQ-29,548 significantly reduced S-T segment elevation (p<0.01) and attenuated the rise in plasma creatine kinase (p<0.05).
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