What is the clinical evidence from this study?

Population: Myocardial infarction. Intervention: U-63,557A or SQ-29,548 vs. Saline. Primary outcome: Myocardial infarct size (as percent of left ventricle) (p=<0.05).

What does this research mean for the field?

Inhibition of thromboxane A2 via synthetase inhibitors or receptor antagonists reduces myocardial infarct size and decreases neutrophil accumulation in the infarcted tissue following coronary ligation. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

March 1, 1989Angiology

Reduced Myocardial Neutrophil Accumulation and Infarct Size Following Thromboxane Synthetase Inhibitor or Receptor Antagonist

Q: What are the key findings of this study?

Pretreatment with U-63,557A or SQ-29,548 decreased myocardial infarct size to 34% and 32% respectively, compared to 44% in saline-treated control rats (P<0.05).

Q: What does this research mean for the field?

Inhibition of thromboxane A2 via synthetase inhibitors or receptor antagonists reduces myocardial infarct size and decreases neutrophil accumulation in the infarcted tissue following coronary ligation. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

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Key result

Pretreatment with U-63,557A or SQ-29,548 decreased myocardial infarct size to 34% and 32% respectively, compared to 44% in saline-treated control rats (P<0.05).

Why the study?

Does pretreatment with TXA2 synthetase inhibitor U-63,557A or TXA2 receptor antagonist SQ-29,548 reduce myocardial infarct size in rats following coronary ligation?

Structured PICO

Does pretreatment with TXA2 synthetase inhibitor U-63,557A or TXA2 receptor antagonist SQ-29,548 reduce myocardial infarct size in rats following coronary ligation?

Population

Rats undergoing left coronary ligation

Intervention

Pretreatment with selective TXA2 synthetase inhibitor U-63,557A or TXA2 receptor antagonist SQ-29,548

Comparator

Saline-treated control

Outcome

Myocardial infarct size (as percent of left ventricle) forty-eight hours following left coronary ligationsurrogate

Main Result

Absolute Event Rate: 34% vs 44%

p-value: p=<0.05

Inhibition of TXA2 synthesis or receptors reduces myocardial infarct size and neutrophil accumulation following coronary ligation in a rat model.

Discussion

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Implication

Does not support clinical use; leaves open whether TXA2 inhibition reduces infarct size in patients.

Cite This Study

Nichols et al. (1989) studied Myocardial infarction. U-63,557A or SQ-29,548 vs. Saline was evaluated on Myocardial infarct size (as percent of left ventricle) (p=<0.05). Pretreatment with U-63,557A or SQ-29,548 decreased myocardial infarct size to 34% and 32% respectively, compared to 44% in saline-treated control rats (P<0.05).

synapsesocial.com/papers/6a15377ccb0379474a8204bf https://doi.org/10.1177/000331978904000309

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Reduced Myocardial Neutrophil Accumulation and Infarct Size Following Thromboxane Synthetase Inhibitor or Receptor Antagonist

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Reduced Myocardial Neutrophil Accumulation and Infarct Size Following Thromboxane Synthetase Inhibitor or Receptor Antagonist

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Also Consider

Also Consider