August 1, 1983British Journal of PharmacologyOpen Access

Ligand binding to thromboxane receptors on human platelets: correlation with biological activity

View Full Paper

Ask AI

Bookmark

Population

Washed human platelets

Design

Preclinical

Authors

RARoma A. ArmstrongQueen Margaret University RJRebecca L. JonesAzienda Ospedaliera Citta' della Salute e della Scienza di Torino NWN.H. WilsonUniversity of Zurich

Discussion

Member takes

Implication

Specific TXA2 receptor binding quantified on platelets; extends receptor pharmacology but leaves clinical translation open.

Structured PICO

Population

Washed human platelets

Intervention

Various thromboxane/endoperoxide analogues, prostaglandins, and inhibitors (e.g., TXA2, PGH2, CTA2, PTA2, EP 045, dazoxiben)

Outcome

Displacement of [3H]-15(S)9, 11-epoxymethano PGH2 and correlation with biological activitysurrogate

This basic science study characterizes the thromboxane receptor on human platelets, demonstrating that ligand binding correlates with biological activity.

Cite This Study

Armstrong et al. (1983) studied this question.

synapsesocial.com/papers/6a702fd92163a0a01bc46762 https://doi.org/10.1111/j.1476-5381.1983.tb10541.x

View Full Paper

Ask AI

Bookmark

Ligand binding to thromboxane receptors on human platelets: correlation with biological activity

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Ligand binding to thromboxane receptors on human platelets: correlation with biological activity

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider