March 1, 1986Journal of Biological ChemistryOpen Access

Identification of a putative thromboxane A2/prostaglandin H2 receptor in human platelet membranes.

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Population

Membranes prepared from human platelets

Design

Preclinical

Authors

DSD L SaussyEli Lilly (United States)DMDale E. Mais1Cellbio (United States)RBRonald M. BurchUniversité de Tours

Discussion

Member takes

Implication

May represent the TXA2/PGH2 receptor on platelets; hypothesis-generating for antiplatelet therapies but should not yet change practice.

Structured PICO

Population

Membranes prepared from human platelets

Intervention

[125I]PTA-OH (a competitive TXA2/PGH2 antagonist) binding assay

Outcome

Binding characteristics (Kd, Bmax) and correlation of binding inhibition with platelet aggregationsurrogate

The characterization of [125I]PTA-OH binding to human platelet membranes provides evidence for a specific binding site that likely represents the TXA2/PGH2 receptor.

Cite This Study

Saussy et al. (1986) studied this question.

synapsesocial.com/papers/6a702f21b5c1fe5ca9dfac76 https://doi.org/10.1016/s0021-9258(17)35740-x

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Identification of a putative thromboxane A2/prostaglandin H2 receptor in human platelet membranes.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Identification of a putative thromboxane A2/prostaglandin H2 receptor in human platelet membranes.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider