March 1, 1991British Journal of PharmacologyOpen Access

Heterogeneity of thromboxane A2(TP‐) receptors: evidence from antagonist but not agonist potency measurements

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Population

Human, rat and rabbit platelets and smooth muscle of guinea-pig trachea, rat aorta and rabbit aorta

Design

Preclinical

Authors

PTP. M. TymkewyczNational Institute for Biological Standards and Control RJRebecca L. JonesAzienda Ospedaliera Citta' della Salute e della Scienza di Torino NWN.H. WilsonUniversity of Zurich

Discussion

Member takes

Implication

TP-receptor heterogeneity indicated by antagonist data; leaves open selective antagonist development for human cardiovascular use.

Structured PICO

Population

Human, rat and rabbit platelets and smooth muscle of guinea-pig trachea, rat aorta and rabbit aorta

Intervention

Prostanoid agonists (e.g., EP 171, STA2, U-46619) and antagonists (e.g., EP 169, AH 23848)

Outcome

Potencies of agonists and antagonists (pA2 values, aggregation, shape change)surrogate

Pharmacological characterization reveals heterogeneity in thromboxane A2 receptors based on antagonist affinities, though agonist recognition sites appear similar across species and tissues.

Cite This Study

Tymkewycz et al. (1991) studied this question.

synapsesocial.com/papers/6a82798580b3939dcdca44fa https://doi.org/10.1111/j.1476-5381.1991.tb12220.x

Topics

Dual antiplatelet therapy

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Heterogeneity of thromboxane A2(TP‐) receptors: evidence from antagonist but not agonist potency measurements

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Heterogeneity of thromboxane A2(TP‐) receptors: evidence from antagonist but not agonist potency measurements

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider