December 1, 1989CirculationOpen Access

Alleviation of myocardial stunning by leukocyte and platelet depletion.

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Why the study?

Does leukocyte and platelet depletion improve subendocardial segmental function in a dog model of myocardial ischemia and reperfusion?

Structured PICO

Does leukocyte and platelet depletion improve subendocardial segmental function in a dog model of myocardial ischemia and reperfusion?

Population

Anesthetized, open-chest dogs subjected to 15 minutes of ischemia and 3 hours of reperfusion (n=20)

Intervention

Leukocyte and platelet depletion using a Leukopak filter in a carotid left anterior descending coronary-artery extracorporeal circuit (either 30 minutes before ischemia or only at reperfusion)

Comparator

Extracorporeal circuit without a Leukopak filter

Outcome

Subendocardial segmental function (contractility) monitored by sonomicrometrysurrogate

Leukocyte and platelet depletion during reperfusion significantly alleviates myocardial stunning and improves contractile function in a canine model of ischemia-reperfusion.

Discussion

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Implication

Hypothesis-generating for leukocyte-platelet roles in canine stunning; leaves open translation to clinical reperfusion.

Cite This Study

Westlin et al. (1989) studied this question.

synapsesocial.com/papers/6a72a457ce524a4339c583fe https://doi.org/10.1161/01.cir.80.6.1828

View Full Paper

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Alleviation of myocardial stunning by leukocyte and platelet depletion.

Structured PICO

Discussion

Implication

Cite This Study

Alleviation of myocardial stunning by leukocyte and platelet depletion.

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider