Why the study?
Does inhibition of 5-lipoxygenase and/or complement depletion reduce leukocyte accumulation and infarct size in rats after coronary artery ligation?
Population
Rats subjected to left main coronary artery ligation
Comparison
5-lipoxygenase inhibitor AA-861, cobra venom… vs Untreated control (implied)
Design
Preclinical
Follow-up
48 hours
Authors
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Supports anti-inflammatory strategies post-MI in rats; leaves open clinical translation in humans.
Does inhibition of 5-lipoxygenase and/or complement depletion reduce leukocyte accumulation and infarct size in rats after coronary artery ligation?
Inhibition of leukotriene B4 synthesis and complement depletion reduces leukocyte accumulation and limits infarct size in a rat model of myocardial infarction.
Katori et al. (1989) studied this question.
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