Key result
Cilazaprilat attenuated postischemic PMN adhesion (83 vs 172 PMN/mm2) and improved recovery of external heart work (64% vs 39%) in isolated guinea pig hearts.
Why the study?
Does cilazaprilat reduce PMN-dependent reperfusion injury in isolated guinea pig hearts?
Population
Isolated guinea pig hearts subjected to 15 min of ischemia followed by injection of polymorphonuclear…
Comparison
Cilazaprilat or nitro-L-arginine vs Control (no drug)
Design
Preclinical
Authors
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Hypothesis-generating in isolated guinea pig hearts; leaves open translation of ACE inhibition to clinical reperfusion injury.
Does cilazaprilat reduce PMN-dependent reperfusion injury in isolated guinea pig hearts?
Absolute Event Rate: 64% vs 39%
ACE-inhibition with cilazaprilat prevents leukocyte-dependent reperfusion injury in isolated guinea pig hearts, likely by inhibiting postcapillary leukocyte adhesion via a nitric oxide-mediated mechanism.
Christian Kupatt (1997) studied Postischemic myocardial reperfusion injury. Cilazaprilat vs. Control (no cilazaprilat) was evaluated on Recovery of external heart work (EHW) and postcapillary PMN adhesion. Cilazaprilat attenuated postischemic PMN adhesion (83 vs 172 PMN/mm2) and improved recovery of external heart work (64% vs 39%) in isolated guinea pig hearts.
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