Key result
Oral cilazapril did not significantly reduce intimal thickening over 3 months in baboon arterial injury models compared to untreated controls (p>0.5 for all sites).
Why the study?
Does oral cilazapril reduce intimal hyperplasia in injured arteries and vascular grafts in a baboon model?
Population
10 baboons undergoing carotid artery endarterectomy, balloon catheter deendothelialization of the…
Comparison
Oral cilazapril initiated 1 week preoperatively… vs Untreated control animals.
Design
Preclinical
Follow-up
3 months
Authors
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Negative baboon result tempers expectations for ACE inhibition in vascular injury; leaves open human translation.
Does oral cilazapril reduce intimal hyperplasia in injured arteries and vascular grafts in a baboon model?
p-value: p=>0.5
In a baboon model of arterial injury, ACE inhibition with cilazapril did not significantly reduce intimal thickening over 3 months.
Hanson et al. (1991) studied Arterial proliferative lesions / intimal hyperplasia (n=10). Cilazapril vs. Untreated control was evaluated on Cross-sectional area of neointima at sites of carotid endarterectomy, femoral artery ballooning, or graft anastomoses (p=>0.5). Oral cilazapril did not significantly reduce intimal thickening over 3 months in baboon arterial injury models compared to untreated controls (p>0.5 for all sites).
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