Why the study?
Does captopril increase VSMC apoptosis and reduce neointimal formation in a rat model of carotid artery balloon injury?
Population
Male Sprague-Dawley rats subjected to carotid artery balloon injury
Comparison
1 mg/ml captopril in drinking water vs Standard diet (control)
Design
Preclinical, randomised
Follow-up
14 days
Authors
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Hypothesis-generating for ACE inhibition in restenosis; extends rat vascular injury models but should not yet change practice.
Does captopril increase VSMC apoptosis and reduce neointimal formation in a rat model of carotid artery balloon injury?
Captopril inhibits neointimal formation after arterial injury in rats by inducing vascular smooth muscle cell apoptosis.
Anne Mette Holm (2000) studied this question.
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