Participation of kinins in the captopril‐induced inhibition of intimal hyperplasia caused by interruption of carotid blood flow in the mouse

J129Sv wild-type mice (B(2)(+/+)) and B(2) receptor gene knockout mice (B(2)(-/-)) subjected to ligation of the left carotid artery

Captopril (120 mg kg(-1) per day in drinking water) alone or in combination with bradykinin B1 receptor antagonist DALBK (50 nmol kg(-1) per day, intraperitoneally) or B2 receptor antagonist icatibant (1 micromol kg(-1) per day, intraperitoneally)

Normal tap water (untreated)

Structural alterations (intimal hyperplasia and media thickening) measured by morphometric analysis 14 days after surgerysurrogate