Why the study?
Does oral perindopril reduce smooth muscle cell proliferation and alter growth factor biosynthesis in balloon catheter-injured rat carotid arteries?
Population
Rat carotid arteries subjected to balloon catheter injury
Comparison
Oral perindopril vs Untreated injured vessels (implied)
Design
Preclinical
Follow-up
Up to 10 days after injury
Authors
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Hypothesis-generating for ACE inhibition in restenosis; prospective human trials needed before clinical consideration.
Does oral perindopril reduce smooth muscle cell proliferation and alter growth factor biosynthesis in balloon catheter-injured rat carotid arteries?
ACE inhibition with perindopril attenuates neointima formation in injured rat carotid arteries by abolishing PDGF-AB biosynthesis and reducing early medial smooth muscle cell proliferation.
Wong et al. (1997) studied this question.
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