Why the study?
Does a single-bolus luminal delivery of antisense PDGFR-beta reduce intimal hyperplasia in a rat carotid injury model?
Population
Rat carotid injury model
Comparison
Single-bolus luminal delivery of antisense… vs Injured untreated carotids
Design
Preclinical
Follow-up
28 days
Authors
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Does not support clinical use; leaves open antisense PDGFR-beta for human restenosis prevention.
Does a single-bolus luminal delivery of antisense PDGFR-beta reduce intimal hyperplasia in a rat carotid injury model?
Local endovascular delivery of antisense PDGFR-beta suppresses intimal hyperplasia and promotes vascular healing in a preclinical model of arterial injury.
Noiseux et al. (2000) studied this question.
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