Why the study?
Is leukotriene production increased in patients with acute and chronic lower limb ischemia compared to healthy volunteers?
Is leukotriene production increased in patients with acute and chronic lower limb ischemia compared to healthy volunteers?
Leukotriene production is significantly increased in both acute and chronic lower limb ischemia, likely reflecting leukocyte activation due to insufficient blood flow or tissue injury.
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LTE4 elevation may mark ischemia-related inflammation; hypothesis-generating for targeted therapies but should not change practice.
Leukotrienes, derived from arachidonic acid by the 5-lipoxygenase pathway, have been implicated in unstable angina and in acute myocardial infarction. The aim of the present study was to investigate if leukotriene production is increased in acute and chronic lower limb ischemia. Leukotriene E 4 excretion was increased in both acute (152 ± 38 pg/mg creatinine, mean ± SEM, n=11, p < 0.001) and chronic (140 ± 45 pg/mg creatinine, n=8, p < 0.001) lower limb ischemia about 7-fold compared with healthy volunteers (22 ± 3 pg/mg creatinine, n = 17). Leukotriene synthesis seems to be increased because of insufficience of blood flow and microcirculation or acute tissue injury. We propose that increased leukotriene synthesis in lower limb ischemia reflects leukocyte activation.
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Rossi et al. (2005) studied this question.
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