Why the study?
Does intravenous low-dose aspirin compared to coronary dilators alter the relationship between platelet activation and spontaneous myocardial ischemia in patients with unstable angina?
Population
21 patients with unstable angina pectoris, along with 8 patients undergoing PTCA and 6 patients with…
Comparison
Intravenous low-dose aspirin vs Intravenous isosorbide dinitrate and oral…
Design
RCT, Randomized to i.v. low-dose aspirin or i.v. isosorbide dinitrate and oral…
Authors
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Episodic platelet activation and spontaneous ischemia appear independently triggered in unstable angina; challenges assumptions of direct temporal linkage in acute coronary syndromes.
Does intravenous low-dose aspirin compared to coronary dilators alter the relationship between platelet activation and spontaneous myocardial ischemia in patients with unstable angina?
In unstable angina, episodic platelet activation and spontaneous myocardial ischemia are infrequently associated temporally, suggesting they are triggered by independent mechanisms.
Véjar et al. (1990) studied this question.
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