Why the study?
Does picotamide reduce myocardial ischemia compared to aspirin in patients with unstable angina?
Population
Patients with unstable angina, stable effort angina, and controls. The randomized trial portion included the…
Comparison
Picotamide 1200 mg/day vs Aspirin 325 mg/day
Design
RCT, Randomized, Double-blind
Authors
Loading...
Picotamide outperforms aspirin for ischemia reduction in unstable angina; challenges aspirin monotherapy and extends dual TxA2 inhibition evidence.
Does picotamide reduce myocardial ischemia compared to aspirin in patients with unstable angina?
Picotamide, a dual TxA2-synthase inhibitor and receptor antagonist, effectively controls myocardial ischemia in unstable angina, suggesting monocyte-derived TxA2 contributes to its pathogenesis.
Serneri et al. (1994) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: