Why the study?
How does platelet TXA2 synthesizing activity change during acute myocardial infarction and effort angina, and is it affected by ticlopidine?
Population
74 subjects, including 38 patients with acute myocardial infarction, 23 patients with effort angina, and 13…
Comparison
Measurement of platelet TXA2 synthesizing… vs Healthy controls and pre-treatment baseline.
Design
Cohort
Follow-up
Up to 10+ days for AMI patients
Authors
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TXA2 activity rises acutely in AMI and post-exercise in angina; ticlopidine suppression linked to tolerance gains but hypothesis-generating, needs RCTs.
How does platelet TXA2 synthesizing activity change during acute myocardial infarction and effort angina, and is it affected by ticlopidine?
Platelet TXA2 synthesizing activity fluctuates during the acute phase of myocardial infarction and increases after exercise in effort angina, which can be suppressed by ticlopidine to improve exercise tolerance.
YAMAZAKI et al. (1987) studied this question.
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