Key result
Patients with effort and variant angina had significantly higher peripheral thromboxane B2 levels compared to normal subjects (505 and 802 pg/ml vs 254 pg/ml; p<0.01).
Why the study?
Are thromboxane B2 levels elevated in patients with classic and variant angina pectoris compared to normal subjects?
Population
30 patients with angina pectoris and 24 normal subjects.
Design
Cross-sectional
Authors
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TXB2 elevation was associated with effort/variant angina; hypothesis-generating for TXA2-targeted therapies, should not yet change practice.
Observational (n=54)
Are thromboxane B2 levels elevated in patients with classic and variant angina pectoris compared to normal subjects?
p-value: p=<0.01
Increased thromboxane A2 production in the coronary circulation is associated with pacing-induced myocardial ischemia and may contribute to coronary vasospasm and angina.
Tada et al. (1981) conducted an observational in Angina pectoris (n=54). Angina pectoris vs. Normal subjects was evaluated on Peripheral plasma levels of thromboxane B2 (TXB2) (p=<0.01). Patients with effort and variant angina had significantly higher peripheral thromboxane B2 levels compared to normal subjects (505 and 802 pg/ml vs 254 pg/ml; p<0.01).
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