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This report aims to highlight the link between generalized tonic-clonic seizures and subsequent rhabdomyolysis leading to acute kidney injury.

March 24, 2026CureusOpen Access

When a Seizure Is Not Just a Seizure: Rhabdomyolysis and Acute Kidney Injury as a Reminder to Check Creatine Kinase

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Case report reveals severe rhabdomyolysis and acute kidney injury post seizure, indicating the need for creatine kinase monitoring.

This report aims to highlight the link between generalized tonic-clonic seizures and subsequent rhabdomyolysis leading to acute kidney injury.
Described a case of a 53-year-old man with generalized tonic-clonic seizure and collapse.
Conducted extensive biochemical testing, including creatine kinase and renal function assessments.
Utilized neuroimaging and cerebrospinal fluid analysis to rule out other neurological causes.
Administered intravenous fluid resuscitation and electrolyte correction.
The patient developed severe rhabdomyolysis with creatine kinase levels exceeding 89,000 IU/L.
Acute kidney injury progressed to stage three but improved with treatment.
Early monitoring of creatine kinase aided in timely management and recovery.

Alsherbeeny et al. (2026) studied this question.

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