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March 25, 2026Biology of Sex DifferencesOpen Access

Sex-specific associations of SHBG, testosterone, and obesity with cholecystectomy risk: a population-based cohort study

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Authors

JLJie‐Qiong LyuYLYuejia LuoYQYu-Wen Qian

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Overview

Cohort study demonstrates sex differences in hormone impacts on gallbladder surgery risk, suggesting tailored prevention strategies.

Key Points

  • This research aims to explore how SHBG and testosterone levels relate to cholecystectomy risk in men and women, particularly in the context of obesity.
  • Included 337,056 participants from the UK Biobank, stratified by sex.
  • Measured SHBG and testosterone levels using immunoassays.
  • Identified cholecystectomy cases through hospital records.
  • Utilized multivariable Cox proportional hazards models for hazard ratio calculations.
  • Conducted mediation analyses to evaluate the role of hormones in the obesity-gallbladder disease connection.
  • 2,877 men and 4,607 women underwent cholecystectomy during the study period.
  • Higher SHBG levels correlate with lower cholecystectomy risk, particularly in women.
  • Elevated testosterone levels increase cholecystectomy risk only in women.
  • Obesity is more strongly linked to cholecystectomy in women than men.
  • SHBG mediates a notable portion of the obesity-cholecystectomy relationship in women, whereas testosterone's effect is minimal.

Cite This Study

Lyu et al. (2026) studied this question.

synapsesocial.com/papers/69c37afeb34aaaeb1a67d09ahttps://doi.org/10.1186/s13293-026-00884-y
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hepatic steatosis mediates the relationship between cholecystectomy and BMI increase: a population-based study2025
  2. 2Effect modification by levels of sex hormones in the association between adiposity and cancer incidence in the UK Biobank2025
  3. 3Abstract 3434: Effect modification by levels of sex hormones in the association between adiposity and cancer incidence in the UK Biobank2024
  4. 4Blood lipid levels mediating the effects of sex hormone-binding globulin on coronary heart disease: Mendelian randomization and mediation analysis2024 · 3 citations
  5. 5Cholecystectomy effectively reduces the gallstones-induced risk of some gastrointestinal tumors: A real-world study2024