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October 2, 2025Cancer Prevention Research

Effect modification by levels of sex hormones in the association between adiposity and cancer incidence in the UK Biobank

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Authors

LLLeeAnn LucasYLYujia LuEGE. Giovannucci

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Overview

Cohort analysis demonstrates significant cancer risk variance based on adiposity and sex hormones in males and females.

Key Points

  • Hazard ratios indicate that BMI is linked to a higher cancer risk, particularly in males with high SHBG levels.
  • Among 451,500 UK Biobank participants, 42,949 cancers were documented over a median follow-up of 13.1 years.
  • Cox regression models highlighted differing impacts of adiposity on esophageal, liver, and colorectal cancers based on sex hormone levels.
  • The findings suggest that sex hormone binding globulin may significantly influence adiposity-related cancer risks.

Cite This Study

Lucas et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a2187ahttps://doi.org/10.1158/1940-6207.capr-25-0246
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract 3434: Effect modification by levels of sex hormones in the association between adiposity and cancer incidence in the UK Biobank2024
  2. 2The association between low sex hormone binding globulin and increased risk of type 2 diabetes is mediated by increased visceral and liver fat: results from observational and Mendelian randomization analyses2024 · 17 citations
  3. 3Data from Circulating Sex Hormone Levels and Risk of Gastrointestinal Cancer: Systematic Review and Meta-Analysis of Prospective Studies2024
  4. 4Sex-specific associations of SHBG, testosterone, and obesity with cholecystectomy risk: a population-based cohort study2026
  5. 5Associations between sex hormones and obesity-related indicators: results from the NHANES and Mendelian randomization study2025 · 3 citations