Key result
Circulating levels of sex hormones and SHBG were generally not associated with the risk of cancers of the pancreas (225 cases), kidney (749 cases), and brain (467 cases) among 425,793 participants.
Why the study?
Endogenous levels of sex hormones might influence the etiology of cancers of the pancreas, kidney, and brain, but epidemiologic data are lacking.
Are circulating levels of sex hormones and SHBG associated with the risk of cancers of the pancreas, kidney, and brain?
Cohort (n=425,793)
Are circulating levels of sex hormones and SHBG associated with the risk of cancers of the pancreas, kidney, and brain?
Circulating sex hormones and SHBG show little to no association with the risk of pancreatic, kidney, or brain cancers in a large UK cohort.
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Does not support hormone-based cancer risk assessment in practice; leaves open inverse associations with brain and kidney cancers for prospective study.
Peila et al. (2020) conducted a cohort in Cancers of the pancreas, kidney, and brain (n=425,793). Circulating levels of sex hormones and SHBG was evaluated on Risk of cancers of the pancreas, kidney, and brain. Circulating levels of sex hormones and SHBG were generally not associated with the risk of cancers of the pancreas (225 cases), kidney (749 cases), and brain (467 cases) among 425,793 participants.
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