What question did this study set out to answer?

This review aims to assess the toxicological risks associated with N-nitrosamine impurities in drugs and the effectiveness of various detection methods.

March 25, 2026Toxicology Mechanisms and Methods

Computational toxicology of N -nitrosamine impurities: from molecular structure to regulatory concern

View Full Paper

Ask AI

Bookmark

Authors

RKRupal KushwahNational Institute of Pharmaceutical Education and Research MKMadhavi KumariNational Institute of Pharmaceutical Education and Research PGPrabha GargNational Institute of Pharmaceutical Education and Research

Discussion

Member takes

Implication

This review demonstrates the regulatory safety assessment of N-nitrosamines in drugs, indicating the need for advanced detection methods.

Key Points

This review aims to assess the toxicological risks associated with N-nitrosamine impurities in drugs and the effectiveness of various detection methods.
Reviewed regulatory guidelines from USFDA, WHO, and CDSCO
Discussed conventional analytical methods like LC-MS, GC-MS, and HRMS
Explored recent computational techniques such as QM, QSAR modeling, and AI
N-nitrosamines are identified as potent carcinogens with public health implications
Conventional methods for detecting N-nitrosamines are limited by cost and sensitivity
Computational approaches can estimate carcinogenic potency and identify structural drivers of mutagenicity

Cite This Study

Kushwah et al. (2026) studied this question.

synapsesocial.com/papers/69c37b33b34aaaeb1a67d5ae https://doi.org/10.1080/15376516.2026.2643911

View Full Paper

Ask AI

Bookmark

Computational toxicology of N -nitrosamine impurities: from molecular structure to regulatory concern

Discussion

Member takes

Implication

Key Points

Cite This Study

Computational toxicology of N -nitrosamine impurities: from molecular structure to regulatory concern

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider