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July 26, 2025Molecular Pharmaceutics

Pharmaceutical Nitrosamines: A Comprehensive Review of Health Risks, Detection, Mitigation Strategies Supplemented with CYP450 Interactions as Molecular Simulations for Mechanistic Insight into Carcinogenicity

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Authors

KKKardile Punam KashinathMSMd Samim SardarSRSubhadeep Roy

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Overview

The review analyzes nitrosamines' carcinogenicity, detection methods, and mitigation strategies in pharmaceuticals, highlighting CYP450 interactions.

Key Points

  • Nitrosamines are significant impurities in drugs known for their mutagenic and carcinogenic properties.
  • Comprehensive detection methods such as HPLC, LC-MS, and GC-MS are discussed to monitor nitrosamine contamination.
  • The review emphasizes the importance of risk assessment and mitigation strategies to ensure drug safety.
  • Molecular simulations provide insight into the interactions of nitrosamines with CYP450 isoforms, enhancing understanding of their carcinogenic mechanisms.

Cite This Study

Kashinath et al. (2025) studied this question.

synapsesocial.com/papers/689a0933e6551bb0af8ce542https://doi.org/10.1021/acs.molpharmaceut.4c01173
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Nitrosamine-induced carcinogenesis. The alkylation of nucleic acids of the rat by N-methyl-N-nitrosourea, dimethylnitrosamine, dimethyl sulphate and methyl methanesulphonate1968 · 372 citations
  2. 2Development of Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry Methods for Analysis of DNA Adducts of Formaldehyde and Their Application to Rats Treated with N -Nitrosodimethylamine or 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone2007 · 40 citations
  3. 3Reactions of organolithium compounds with nitrosamines1973 · 20 citations
  4. 4Nuclear Magnetic Resonance and Infrared Study of Hindered Rotation in Nitrosamines1957 · 135 citations
  5. 5Determination of N-Nitrosodimethylamine in Environmental Aqueous Samples by Isotope-Dilution GC/MS–SIM2001 · 37 citations