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Investigate the role of GDF-15 in heart failure and its potential as a biomarker for improved management.

March 25, 2026BiologyOpen Access

The Role of GDF-15 in Heart Failure and Biomarker Potential—From Basic Science to Clinical Praxis

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Investigate the role of GDF-15 in heart failure and its potential as a biomarker for improved management.
Conducted a literature search in PubMed using MeSH terms related to GDF-15 and heart failure.
Included studies published within the last five years and selected earlier data.
Reviewed a total of 115 English articles to assess GDF-15's prognostic value.
GDF-15 is identified as an independent predictor of adverse outcomes in heart failure.
Incorporating GDF-15 into traditional risk scores enhances prognostic accuracy.
The biomarker shows limited tissue specificity, impacting its diagnostic effectiveness.

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A review finds GDF-15 improves heart failure prognosis, suggesting its potential as a clinical biomarker.

Barbosa et al. (2026) studied this question.

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