August 1, 2024HeliyonOpen Access

Association between growth differentiation factor-15 and adverse outcomes among patients with heart failure: A systematic literature review

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Elevated growth differentiation factor-15 independently predicts increased mortality and adverse clinical outcomes, including worsening renal function in heart failure.
All-cause mortality was significantly elevated in 92% of multivariate analyses, and 80% of studies confirmed higher cardiovascular-related mortality with elevated baseline GDF-15.
Systematic review of 63 publications across Embase and Medline synthesized longitudinal and cross-sectional evidence, highlighting potential utility for heart failure risk models.

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Implication

Systematic review reveals elevated growth differentiation factor-15 predicts adverse outcomes in heart failure, suggesting its value for improving clinical risk prediction models.

Cite This Study

Javaheri et al. (2024) studied this question.

synapsesocial.com/papers/68e5dc63b6db643587572825 https://doi.org/10.1016/j.heliyon.2024.e35916

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Implication

Systematic review reveals elevated growth differentiation factor-15 predicts adverse outcomes in heart failure, suggesting its value for improving clinical risk prediction models.

Association between growth differentiation factor-15 and adverse outcomes among patients with heart failure: A systematic literature review

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Discussion

Implication

Cite This Study

Association between growth differentiation factor-15 and adverse outcomes among patients with heart failure: A systematic literature review

Key Points

Discussion

Implication

Cite This Study

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