Key result
Plasma GDF-15 levels in the highest tertile were independently associated with an increased risk of all-cause mortality (HR 5.95) compared to the lowest tertile in Chinese patients with heart failure.
Why the study?
Does elevated GDF-15 predict all-cause mortality and heart failure readmission in Chinese patients with heart failure?
Observational (n=272)
No
Does elevated GDF-15 predict all-cause mortality and heart failure readmission in Chinese patients with heart failure?
Hazard Ratio: 5.95 (95% CI 1.88–18.78)
Absolute Event Rate: 36.7% vs 4.4%
p-value: p=0.002
Elevated plasma GDF-15 is an independent predictor of all-cause mortality and major adverse cardiac events in Chinese patients with heart failure.
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May aid mortality risk stratification in Chinese HF; leaves open incremental value and generalizability in prospective studies.
Wang et al. (2013) conducted an observational in Heart failure (n=272). Growth differentiation factor-15 (GDF-15) highest tertile vs. GDF-15 lowest tertile was evaluated on All-cause mortality (HR 5.95, 95% CI 1.88-18.78, p=0.002). Plasma GDF-15 levels in the highest tertile were independently associated with an increased risk of all-cause mortality (HR 5.95) compared to the lowest tertile in Chinese patients with heart failure.
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