Key result
Elevated baseline GDF-15 levels independently predicted an increased risk of all-cause death (HR 1.826 per 1 Ln U increase) in Chinese Han patients with post-myocardial infarction chronic heart failure.
Why the study?
Does baseline and repeated measurement of GDF-15 predict all-cause death and MACE in Chinese Han patients with post-myocardial infarction chronic heart failure?
Observational (n=232)
No
Does baseline and repeated measurement of GDF-15 predict all-cause death and MACE in Chinese Han patients with post-myocardial infarction chronic heart failure?
Hazard Ratio: 1.826 (95% CI 1.037–8.36)
p-value: p=0.037
Baseline and repeated measurements of GDF-15 provide independent prognostic value for predicting all-cause death and MACE in Chinese Han patients with post-myocardial infarction chronic heart failure.
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May refine post-MI HF prognostication in Chinese patients; hypothesis-generating, requires prospective validation before practice change.
Liu et al. (2018) conducted an observational in Post-myocardial infarction chronic heart failure (n=232). Growth-differentiation factor-15 (GDF-15) vs. Lower GDF-15 levels was evaluated on All-cause death (HR 1.826, 95% CI 1.037-8.360, p=0.037). Elevated baseline GDF-15 levels independently predicted an increased risk of all-cause death (HR 1.826 per 1 Ln U increase) in Chinese Han patients with post-myocardial infarction chronic heart failure.
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