Phosphine-catalyzed β-C(sp³)-H Functionalization of Cyclic Amines via a Halogen Based Frustrated Radical Pairs Approach

Key Points

• The aim is to develop a method for β-position functionalization of cyclic amines using phosphine catalysis.
• Utilized phosphine as a catalyst in the functionalization process.
• Explored halogen-based frustrated radical pairs for enhanced reactivity.
• Focused on nitrogen-containing heterocycles in the synthesis.
• Successfully achieved β-C(sp³)-H functionalization of various cyclic amines.
• Demonstrated improved efficiency compared to traditional methods.
• Highlighted potential applications in drug discovery through precise modifications.