Experimental findings demonstrate enhanced cancer treatment effectiveness through AQP5 reduction, suggesting novel therapeutic targets.
Our findings demonstrate that AQP5 plays a key role in mediating resistance to radiotherapy in PDAC. Its downregulation through combined hyperthermia and radiotherapy enhances radiosensitivity by promoting oxidative stress and blocking survival pathways. AQP5 may serve as a promising molecular target to improve the therapeutic efficacy of combined treatment strategies in pancreatic cancer.
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Jeon et al. (2026) studied this question.
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