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March 25, 2026NanomaterialsOpen Access

A Facile Nanocarrier for Paclitaxel Delivery Based on Carboxymethyl Chitosan Encapsulated 6-Deoxy-6-Mercapto-β-Cyclodextrin Grafted Concave Cubic Gold

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Authors

HLHui LiLZLin ZhangYLYou Long

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Overview

Research demonstrates enhanced paclitaxel delivery in cancer cells using a novel nanocarrier approach, indicating improved treatment potential.

Key Points

  • This research aims to develop an effective nanocarrier system for the delivery of paclitaxel to enhance its bioavailability.
  • Synthesize concave cubic gold nanoparticles using a one-pot method.
  • Modify gold nanoparticles with 6-deoxy-6-mercapto-β-cyclodextrins (dmβCDs).
  • Encapsulate the modified gold with carboxymethyl chitosan (CMCS) to form nanocarriers.
  • Conduct drug loading and drug release experiments to evaluate performance.
  • Synthesis produced hexagonal concave cubic gold nanoparticles approximately 50 nm in size.
  • The nanocarrier effectively encapsulated paclitaxel with a capacity of 55.05 µg/mL.
  • Drug release showed pH-responsive characteristics, with enhanced release in acidic environments.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/69c37b93b34aaaeb1a67e23ehttps://doi.org/10.3390/nano16060378
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