What question did this study set out to answer?

Examine the effects of gp120 on inflammation and cardiovascular health in individuals on antiretroviral therapy.

March 25, 2026Acta Microbiologica HellenicaOpen Access

The Inflammatory, Apoptotic, and Cardiovascular Role of Soluble and Tissue Gp120 in PLWH on Antiretroviral Therapy: Is Anti-gp120 Therapy Needed?

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This review discusses the role of gp120 in inflammation and cardiovascular issues in PLWH, suggesting anti-gp120 therapy may be beneficial.

Examine the effects of gp120 on inflammation and cardiovascular health in individuals on antiretroviral therapy.
Review biological effects of gp120 related to immune activation and systemic inflammation.
Analyze the role of soluble gp120 in cytokine signaling and endothelial injury.
Evaluate the potential therapeutic benefits of targeting gp120 with agents like fostemsavir.
Gp120 is linked to chronic inflammation and may lead to neurodegenerative and cardiovascular complications.
Increased levels of pro-inflammatory cytokines like IL-6 and TNF-α are associated with gp120.
Fostemsavir may reduce gp120-mediated inflammation and its harmful effects.

Mirabile et al. (2026) studied this question.

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This review discusses the role of gp120 in inflammation and cardiovascular issues in PLWH, suggesting anti-gp120 therapy may be beneficial.