Estimating prognosis in patients with acute myocardial infarction using personalized computational heart models

12 subjects: 6 patients with acute STEMI complicated by left ventricular (LV) systolic dysfunction (83% male, age 54 ± 12 years) and 6 age- and sex-matched healthy controls (83% male, age 46 ± 14 years, no prior history of cardiovascular disease, SBP < 130 mmHg).

Personalized biomechanical computational heart models synthesized from Cardiac MRI performed 2 days and 6 months post-STEMI to determine myocardial contractility and active tension.

Age- and sex-matched healthy controls undergoing the same cardiac MRI and biomechanical computational heart modeling.

Relationship between active tension at the resting sarcomere length (T req) 2 days post-MI and global longitudinal strain 6 months later.surrogate