Why the study?
Does LGE predict the heterogeneity of intramural contractile abnormalities in patients with HCM?
Does LGE predict the heterogeneity of intramural contractile abnormalities in patients with HCM?
Myocardial scarring assessed by LGE does not fully explain contractile heterogeneity in HCM, suggesting that myofibril disarray or other nonfibrotic processes significantly affect systolic function.
LGE incompletely explains contractile heterogeneity in HCM; hypothesis-generating for non-scarring mechanisms such as myofibril disarray.
LGE predicted some but not all of the heterogeneity of intramural contractile abnormalities. This indicates that myocardial scarring or excess interstitial collagen deposition does not fully explain the observed contractile heterogeneity in HCM. Thus, myofibril disarray or other nonfibrotic processes affect systolic function in a large number of patients with HCM.
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Aletras et al. (2011) studied this question.
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